Antineuronal antibody status and phenotype analysis in Tourette's syndrome
Identifieur interne : 003019 ( Main/Exploration ); précédent : 003018; suivant : 003020Antineuronal antibody status and phenotype analysis in Tourette's syndrome
Auteurs : Davide Martino [Royaume-Uni, Italie] ; Giovanni Defazio [Italie] ; Andrew J. Church [Royaume-Uni] ; Russell C. Dale [Royaume-Uni] ; Gavin Giovannoni [Royaume-Uni] ; Mary M. Robertson [Royaume-Uni] ; Michael Orth [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-07-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- ADHD, Adolescent, Adult, Antibodies (metabolism), Attention disorder with hyperactivity, Attentional disorder, Blotting, Western (methods), Child, Enzyme-Linked Immunosorbent Assay (methods), Female, Gilles de la Tourette syndrome, Humans, Hyperactivity, Logistic Models, Male, Molecular Weight, Nerve Tissue Proteins (immunology), Nervous system diseases, OCD, Phenotype, Retrospective Studies, Tourette Syndrome (immunology), Tourette Syndrome (pathology), Tourette Syndrome (physiopathology), antineuronal antibodies, cortico‐striatal‐thalamo‐cortical circuitry.
- MESH :
- chemical , immunology : Nerve Tissue Proteins.
- chemical , metabolism : Antibodies.
- immunology : Tourette Syndrome.
- methods : Blotting, Western, Enzyme-Linked Immunosorbent Assay.
- pathology : Tourette Syndrome.
- physiopathology : Tourette Syndrome.
- Adolescent, Adult, Child, Female, Humans, Logistic Models, Male, Molecular Weight, Phenotype, Retrospective Studies.
Abstract
The Gilles de la Tourette syndrome (GTS) spectrum includes psychiatric comorbidities, mainly obsessive–compulsive disorder (OCD) and attention‐deficit‐hyperactivity disorder (ADHD). The role of environmental factors, e.g., antineuronal antibodies (ANeA), remains unclear. We compared the clinical features of ANeA‐positive and ANeA‐negative patients in 53 children and 75 adults with GTS. All diagnoses were made according to DSM‐IV‐TR criteria. A positive ANeA Western immunoblot showed bands for at least 1 of 3 reported striatal antigens (40, 45, and 60 kDa). Twelve children (23%) and 18 adults (25%) with GTS were ANeA‐positive. Disease duration, tic phenomenology and severity, frequency of echo/pali/coprophenomena, self‐injurious and aggressive behavior, or frequency of OCD comorbidity did not significantly differ between ANeA‐positive and negative patients. Similar findings were obtained analyzing separately the three different antibody reactivities. A comorbid diagnosis of ADHD was significantly less frequent in GTS patients positive for the anti‐60 kDa antibody only. Using a multivariate logistic regression model, adjusting for age, gender, and age at disease onset, a comorbid diagnosis of ADHD remained inversely associated with anti‐60 kDa antibodies (odds ratio = 0.14; P = 0.002; 95% confidence interval 0.04–0.49). ANeA status does not differentiate a specific phenotype of GTS. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21454
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001800
- to stream Istex, to step Curation: 001800
- to stream Istex, to step Checkpoint: 001B27
- to stream PubMed, to step Corpus: 002717
- to stream PubMed, to step Curation: 002717
- to stream PubMed, to step Checkpoint: 002976
- to stream Ncbi, to step Merge: 001C22
- to stream Ncbi, to step Curation: 001C22
- to stream Ncbi, to step Checkpoint: 001C22
- to stream Main, to step Merge: 003F41
- to stream PascalFrancis, to step Corpus: 001594
- to stream PascalFrancis, to step Curation: 001727
- to stream PascalFrancis, to step Checkpoint: 001795
- to stream Main, to step Merge: 004385
- to stream Main, to step Curation: 003019
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antineuronal antibody status and phenotype analysis in Tourette's syndrome</title><author><name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name></author><author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name></author><author><name sortKey="Church, Andrew J" sort="Church, Andrew J" uniqKey="Church A" first="Andrew J." last="Church">Andrew J. Church</name></author><author><name sortKey="Dale, Russell C" sort="Dale, Russell C" uniqKey="Dale R" first="Russell C." last="Dale">Russell C. Dale</name></author><author><name sortKey="Giovannoni, Gavin" sort="Giovannoni, Gavin" uniqKey="Giovannoni G" first="Gavin" last="Giovannoni">Gavin Giovannoni</name></author><author><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DA8FCB7BDDA5838ACECE8D167F0465097C79BB69</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21454</idno><idno type="url">https://api.istex.fr/document/DA8FCB7BDDA5838ACECE8D167F0465097C79BB69/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001800</idno><idno type="wicri:Area/Istex/Curation">001800</idno><idno type="wicri:Area/Istex/Checkpoint">001B27</idno><idno type="wicri:doubleKey">0885-3185:2007:Martino D:antineuronal:antibody:status</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:17516471</idno><idno type="wicri:Area/PubMed/Corpus">002717</idno><idno type="wicri:Area/PubMed/Curation">002717</idno><idno type="wicri:Area/PubMed/Checkpoint">002976</idno><idno type="wicri:Area/Ncbi/Merge">001C22</idno><idno type="wicri:Area/Ncbi/Curation">001C22</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C22</idno><idno type="wicri:doubleKey">0885-3185:2007:Martino D:antineuronal:antibody:status</idno><idno type="wicri:Area/Main/Merge">003F41</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:07-0393262</idno><idno type="wicri:Area/PascalFrancis/Corpus">001594</idno><idno type="wicri:Area/PascalFrancis/Curation">001727</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001795</idno><idno type="wicri:doubleKey">0885-3185:2007:Martino D:antineuronal:antibody:status</idno><idno type="wicri:Area/Main/Merge">004385</idno><idno type="wicri:Area/Main/Curation">003019</idno><idno type="wicri:Area/Main/Exploration">003019</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Antineuronal antibody status and phenotype analysis in Tourette's syndrome</title><author><name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuroinflammation, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological and Psychiatric Sciences, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological and Psychiatric Sciences, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Church, Andrew J" sort="Church, Andrew J" uniqKey="Church A" first="Andrew J." last="Church">Andrew J. Church</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuroinflammation, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Dale, Russell C" sort="Dale, Russell C" uniqKey="Dale R" first="Russell C." last="Dale">Russell C. Dale</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuroinflammation, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosciences Unit, Great Ormond Street Hospital NHS Trust and Institute of Child Health, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Giovannoni, Gavin" sort="Giovannoni, Gavin" uniqKey="Giovannoni G" first="Gavin" last="Giovannoni">Gavin Giovannoni</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neuroinflammation, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Mental Health Sciences, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Current Address: Department of Neurology, St. George's Hospital and Medical School, Blackshaw Road, Tooting London, SW17 0QT</wicri:regionArea><wicri:noRegion>SW17 0QT</wicri:noRegion></affiliation></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-07-30">2007-07-30</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1424">1424</biblScope><biblScope unit="page" to="1429">1429</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DA8FCB7BDDA5838ACECE8D167F0465097C79BB69</idno><idno type="DOI">10.1002/mds.21454</idno><idno type="ArticleID">MDS21454</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADHD</term><term>Adolescent</term><term>Adult</term><term>Antibodies (metabolism)</term><term>Attention disorder with hyperactivity</term><term>Attentional disorder</term><term>Blotting, Western (methods)</term><term>Child</term><term>Enzyme-Linked Immunosorbent Assay (methods)</term><term>Female</term><term>Gilles de la Tourette syndrome</term><term>Humans</term><term>Hyperactivity</term><term>Logistic Models</term><term>Male</term><term>Molecular Weight</term><term>Nerve Tissue Proteins (immunology)</term><term>Nervous system diseases</term><term>OCD</term><term>Phenotype</term><term>Retrospective Studies</term><term>Tourette Syndrome (immunology)</term><term>Tourette Syndrome (pathology)</term><term>Tourette Syndrome (physiopathology)</term><term>antineuronal antibodies</term><term>cortico‐striatal‐thalamo‐cortical circuitry</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antibodies</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Blotting, Western</term><term>Enzyme-Linked Immunosorbent Assay</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Molecular Weight</term><term>Phenotype</term><term>Retrospective Studies</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Gilles de la Tourette syndrome</term><term>Hyperactivité</term><term>Phénotype</term><term>Système nerveux pathologie</term><term>Trouble attention</term><term>Trouble déficitaire de l'attention avec hyperactivité</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Gilles de la Tourette syndrome (GTS) spectrum includes psychiatric comorbidities, mainly obsessive–compulsive disorder (OCD) and attention‐deficit‐hyperactivity disorder (ADHD). The role of environmental factors, e.g., antineuronal antibodies (ANeA), remains unclear. We compared the clinical features of ANeA‐positive and ANeA‐negative patients in 53 children and 75 adults with GTS. All diagnoses were made according to DSM‐IV‐TR criteria. A positive ANeA Western immunoblot showed bands for at least 1 of 3 reported striatal antigens (40, 45, and 60 kDa). Twelve children (23%) and 18 adults (25%) with GTS were ANeA‐positive. Disease duration, tic phenomenology and severity, frequency of echo/pali/coprophenomena, self‐injurious and aggressive behavior, or frequency of OCD comorbidity did not significantly differ between ANeA‐positive and negative patients. Similar findings were obtained analyzing separately the three different antibody reactivities. A comorbid diagnosis of ADHD was significantly less frequent in GTS patients positive for the anti‐60 kDa antibody only. Using a multivariate logistic regression model, adjusting for age, gender, and age at disease onset, a comorbid diagnosis of ADHD remained inversely associated with anti‐60 kDa antibodies (odds ratio = 0.14; P = 0.002; 95% confidence interval 0.04–0.49). ANeA status does not differentiate a specific phenotype of GTS. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name></region><name sortKey="Church, Andrew J" sort="Church, Andrew J" uniqKey="Church A" first="Andrew J." last="Church">Andrew J. Church</name><name sortKey="Dale, Russell C" sort="Dale, Russell C" uniqKey="Dale R" first="Russell C." last="Dale">Russell C. Dale</name><name sortKey="Dale, Russell C" sort="Dale, Russell C" uniqKey="Dale R" first="Russell C." last="Dale">Russell C. Dale</name><name sortKey="Giovannoni, Gavin" sort="Giovannoni, Gavin" uniqKey="Giovannoni G" first="Gavin" last="Giovannoni">Gavin Giovannoni</name><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name><name sortKey="Robertson, Mary M" sort="Robertson, Mary M" uniqKey="Robertson M" first="Mary M." last="Robertson">Mary M. Robertson</name></country><country name="Italie"><noRegion><name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name></noRegion><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003019 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003019 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:DA8FCB7BDDA5838ACECE8D167F0465097C79BB69
|texte= Antineuronal antibody status and phenotype analysis in Tourette's syndrome
}}
| This area was generated with Dilib version V0.6.23. |  |